Journal News Articles
News powered by www.mdlinx.comDoes the standard intravenous solution of fentanyl (50microg/mL) administered intranasally have analgesic efficacy?Crellin D et al. Standard i.v. concentration IN fentanyl (50 microg/mL) appears to have analgesic efficacy in children with upper limb injuries....
Emergency Medicine Australasia, 02/18/2010
Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodoneSaari TI et al. Itraconazole increased the exposure to oxycodone by inhibiting its CYP3A4mediated Ndemethylation. The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioidassociated adverse effects....
European Journal of Clinical Pharmacology, 02/18/2010
First therapy of decompression injuriesCastan J et al. It is very important that a preinformation is sent to the closest hyperbaric chamber as soon as possible since often the chamber needs some time to be properly prepared for usage. In order to receive information regarding the depth where the diving incident occured, the duration of the diving trip and the decompression stops, it is important to secure the diving computer of the victim for the hyperbaric chamber....
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 02/18/2010
Standardizing anesthesia medication drawers using human factors and quality assurance methodsShultz J et al. Implementation of the standardized medication drawer is expected to reduce the likelihood of medication errors. Future research should include testing the clinical implications of this standardization and applying the methodology to other areas....
Canadian Journal of Anesthesia, 02/18/2010
Episodic waveforms in the electroencephalogram during general anaesthesia: a study of patterns of response to noxious stimuliNoxious stimuli reduced the 10Hzscore from 0.25 to 0.20 after intubation and from 0.33 to 0.27 after incision; and high frequency variation index from 2.8 to 2.0 after incision – the classical arousal pattern. The nociceptioninduced reduction in spindles was greater in the lowdose fentanyl group. It is possible to quantify such episodic EEG patterns during general anaesthesia and in this study noxious stimulation tended to reduce the prevalence of these patterns....
Anesthesia and Intensive Care, 02/18/2010
Comparison of two different local anaesthetic infiltrations for postoperative pain relief in tonsillectomy: a prospective, randomised, double blind, clinical trialStelter K et al. Postoperative haemorrhage occurred in two patients without correlation to a certain local anaesthetic. Two patients developed sinus tachycardia for 2.5 min after epinephrine infiltration. Because of costeffectiveness and complication rates, we recommend only posttonsillectomy wound infiltration of bupivacaine. The injection should be placed in superficial muscle and connective tissue. A stringent systemic analgesia regime is indispensable for pain relief after tonsillectomy....
European Archives of Oto-Rhino-Laryngology, 01/15/2010
Buccal administration of dexmedetomidine as a preanesthetic in childrenSakurai Y et al. The objective of this study was to evaluate the efficacy and safety of buccal dexmedetomidine as a preanesthetic in children, to compare it with diazepam, and to investigate the optimal dosage for buccal dexmedetomidine administration by measuring its serum concentration. The results suggest that the buccal administration of dexmedetomidine (3–4 microg/kg) 1 h before the operation can be safely and effectively applied as a preanesthetic in children....
Journal of Anesthesia, 01/15/2010
Impact of gynecological surgery on female sexual functionPauls RN It is critical that physicians remain aware of the potential for negative outcomes. Subjects who experience worsening should undergo thorough evaluation early in the postoperative period in order to mitigate symptoms. Treatment modalities for sexual dysfunction following surgery should be the focus of future research....
International Journal of Impotence Research, 01/15/2010
Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABGMenda F et al. The authors conclude that dexmedetomidine effectively blunts the hemodynamic response to endotracheal intubation in patients undergoing myocardial revascularization and can be safely used at induction of general anesthesiain combination with fentanyl, even among patients receiving beta blockers....
Annals of Cardiac Anaesthesia, 01/15/2010
Semi-elective intraosseous infusion after failed intravenous access in pediatric anesthesiaNeuhaus D et al. Intraosseous (IO) infusion is a wellestablished intervention to obtain vascular access in pediatric emergency medicine but is rarely used in routine pediatric anesthesia. IO access represents a quick and reliable alternative for pediatric patients with prolonged difficult or failed IV access after inhalational induction of anesthesia....
Paediatric Anaesthesia, 01/15/2010
A randomized trial of propofol consumption and recovery profile with BIS-guided anesthesia compared to standard practice in childrenBhardwaj N et al. Titrating propofol administration using BIS reduces its requirement and shortens the recovery from anesthesia in adults. However, there is still mixed evidence for utility of anesthesia depth monitors in reducing anesthesia requirement in children. The study showed no benefit of BISguided propofol administration on anesthetic consumption or recovery compared to standard anesthetic practice....
Paediatric Anaesthesia, 01/15/2010
Screening for deep venous thrombosis after idiopathic scoliosis surgery in children: a pilot studyKaabachi O et al. Thromboembolic event seems to be rare after scoliosis surgery. Prophylaxis for venous thrombosis should not be recommended in such patient. But, larger series are required to confirm such results....
Paediatric Anaesthesia, 01/15/2010
Hypercapnia test and weaning outcome from mechanical ventilation in COPD patientsCOPD patients with weaning failure have a significantly more blunted response to the hypercapnia response test than weaning success patients. This test could be useful to predict weaning failure patients if the combined values of the hypercapnic drive and hypercapnic ventilatory response were below the threshold values....
Anesthesia and Intensive Care, 01/15/2010
Noninvasive and invasive ventilation in acute respiratory failure associated with bronchiectasisPhua J et al. The hospital mortality of patients with bronchiectasis and ARF approximates 25% and is predicted by the APACHE II score. When selectively applied, NIV fails in onethird of the patients, and this is predicted by hypoxemia. The findings call for randomised controlled trials to compare NIV versus IMV in such patients....
Intensive Care Medicine, 01/15/2010
Postoperative analgesia and respiratory events in patients with symptoms of obstructive sleep apnoeaBlake DW et al. In patients at risk of obstructed breathing, intention to treat with an opioidsparing analgesia protocol did not decrease the rate of respiratory events, although the rate was still related to the total morphine dose....
Anesthesia and Intensive Care, 01/15/2010
Incidence and risk factors for chronic pain after caesarean section under spinal anaesthesiaSng BL et al. A total of 857 subjects completed both the perioperative study and phone survey. The incidence of wound scar pain for three months after surgery was 9.2% (79). Of the 51 subjects with persistent pain at the time of subsequent survey, 9.8% (n=5) had constant pain, 9.8% (n=5) had daily pain and 23.5% (n=12) had pain intermittently, at an interval of days. The independent risk factors for development of chronic pain were higher pain scores recalled in the immediate postoperative period (odds ratio [OR, 95% confidence interval] 1.348 [1.219 to 1.490], P=0.0001), pain present elsewhere (OR 2.471 [1.485 to 4.112], P=0.001) and nonprivate insurance status (OR 1.679 [1.034 to 2.727], P=0.036). The two most common sites of pain other than wound pain were back pain (n=316) and migraine (n=87)....
Anesthesia and Intensive Care, 01/15/2010
Ambulatory continuous femoral analgesia for major knee surgery: a randomised study of ultrasound-guided femoral catheter placementFredrickson MJ et al. Femoral nerve catheters placed for major knee surgery using an ultrasound endpoint provided postoperative analgesia comparable to that obtained when using a nerve stimulation endpoint and were associated with a reduction in both needle manipulations and procedurerelated pain....
Anesthesia and Intensive Care, 01/15/2010
Cardiac pacing in left bundle branch/ bifascicular block patientsMaddali MM It is important that an anesthesiologist should be aware of the indications for temporary cardiac pacing as well as the current recommendations for permanent pacing in patients with chronic bifascicular and trifascicular block. This article also highlights the recent guidelines for temporary transvenous pacing in the setting of acute MI and the different pacing modalities that are available for an anesthesiologist....
Annals of Cardiac Anaesthesia, 01/15/2010
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